quintiles of enzymes like gamma-glutamyl transferase, alkaline phosphatase, and lactate dehydrogenase were tied to lower odds of exceptional longevity. These enzymes can rise with liver or bile duct problems, alcohol use, certain medications, or other conditions.
Doctors read these markers together, not in isolation. The study also noted a U-shaped link for aspartate aminotransferase. Both very high and very low values are related to lower odds. That pattern tells us extremes can be risky for different reasons. Very low values can track with frailty or poor nutrition in some settings.
